Anti-melanogenic effect of Moju through inhibition of tyrosinase activity

Abstract Background Moju is a traditional rice beverage local to Jeonju with an alcohol content of 1–2%. made by boiling makgeolli several kinds medicinal herbs, such as ginger, jujube and cinnamon. The raw materials used in are well known for their physiological functional effects. Although materials, the operational role has not yet been reported. Objectives aim this study was identify anti-melanogenic effects B16F10 melanoma cells explore potential mechanisms. Results In study, we investigated antioxidant activity effect Moju. showed no toxicity HEK293T or cells. confirmed its ability increase radical scavenging activity. decreased tyrosinase concentration-dependent manner. At cellular level, reduced melanin synthesis expression proteins involved at concentrations 100, 250, 500 μg/mL addition, inhibited phosphorylation extracellular signal-regulated kinase (ERK). Conclusions These results provide evidence that occur through regulation ERK pathway. further research needed elucidate specific mechanism components, inhibit altering activation suggest it can be whitening ingredient.